Monday, Sep 28, 2020 | Last Update : 04:42 PM IST

188th Day Of Lockdown

Maharashtra1339232103001535571 Andhra Pradesh6756746050905708 Tamil Nadu5808085251549313 Karnataka5755664622418582 Uttar Pradesh3870853258885594 Delhi2711142366515235 West Bengal2474252169214781 Odisha209374173571850 Telangana1872111564311107 Bihar178882164537888 Kerala175385117917678 Assam169985139977655 Gujarat1332191132403417 Rajasthan1288591077181441 Haryana1237821059901307 Madhya Pradesh117588932382207 Punjab107096840253134 Chhatisgarh9856566860777 Jharkhand7770964515661 Jammu and Kashmir69832495571105 Uttarakhand4533233642555 Goa3107125071386 Puducherry2548919781494 Tripura2412717464262 Himachal Pradesh136799526152 Chandigarh112128677145 Manipur9791760263 Arunachal Pradesh8649623014 Nagaland5768469311 Meghalaya5158334343 Sikkim2707199431 Mizoram178612880
  Life   Health  30 Jun 2019  Thirdhand smoke equally harmful to cells

Thirdhand smoke equally harmful to cells

ANI
Published : Jun 30, 2019, 11:24 am IST
Updated : Jun 30, 2019, 11:25 am IST

Thirdhand smoke affects cells in humans: Study.

Thirdhand smoke, or THS, results when exhaled smoke and smoke emanating from the tip of burning cigarettes settles on surfaces such as clothing, hair, furniture, and cars. (Photo: Representational/Pixabay)
 Thirdhand smoke, or THS, results when exhaled smoke and smoke emanating from the tip of burning cigarettes settles on surfaces such as clothing, hair, furniture, and cars. (Photo: Representational/Pixabay)

Washington: People often think that thirdhand smoke is not harmful, however, it does affect us negatively. Thirdhand smoke can damage epithelial cells in the respiratory system by stressing cells and causing them to fight for survival, suggests a study.

The study published in the journal 'JAMA Network Open' could assist physicians in treating patients exposed to thirdhand smoke.

 

"Our data show that cells in humans are affected by thirdhand smoke (THS). The health effects of THS, have been studied in cultured cells and animal models, but this is the first study to show a direct effect of thirdhand smoke on gene expression in humans," said Prue Talbot, who led the research.

Thirdhand smoke, or THS, results when exhaled smoke and smoke emanating from the tip of burning cigarettes settles on surfaces such as clothing, hair, furniture, and cars. Not strictly smoke, THS refers to the residues left behind by smoking.

"THS can resurface into the atmosphere and can be inhaled unwillingly by non-smokers," said Giovanna Pozuelos, the first author of the study.

 

The researchers obtained nasal scrapes from four healthy non-smokers who had been exposed to THS for three hours in a laboratory setting.

The researchers then worked to get good quality RNA from the scrapes -- necessary to examine gene expression changes. RNA sequencing identified genes that were over or under-expressed.

They found 382 genes were significantly over-expressed; seven other genes were under-expressed. They then identified pathways affected by these genes.

"THS inhalation for only three hours significantly altered gene expression in the nasal epithelium of healthy non-smokers," said Pozuelos.

"The inhalation altered pathways associated with oxidative stress, which can damage DNA, with cancer being a potential long-term outcome. It's extremely unlikely a three-hour exposure to THS would cause cancer, but if someone lived in an apartment or home with THS or drove a car regularly where THS was present, there could be health consequences," added Pozuelos.

 

Because gene expression in the nasal epithelium is similar to the bronchial epithelium, the researchers also noted that their data is relevant to cells deeper in the respiratory system as well.

Tags: smoking, thirdhand smoke, secondhand smoke, respiratory system