Saturday, Jun 06, 2020 | Last Update : 01:55 AM IST

73rd Day Of Lockdown

Maharashtra77793336812710 Tamil Nadu2725614901223 Delhi250049898659 Gujarat18609126671155 Rajasthan98627104213 Uttar Pradesh92375439245 Madhya Pradesh87622772377 West Bengal68762768355 Bihar4452212028 Karnataka4320161057 Andhra Pradesh4112252971 Haryana3281112324 Telangana31471587105 Jammu and Kashmir3142104835 Odisha247814819 Punjab2415204347 Assam19894434 Kerala158969015 Uttarakhand115328610 Jharkhand7642975 Chhatisgarh6781892 Tripura6221730 Himachal Pradesh3691636 Chandigarh3022225 Goa126570 Manipur124110 Puducherry90330 Nagaland8000 Arunachal Pradesh3710 Meghalaya33131 Mizoram1710 Sikkim200

Dopamine and serotonin play significant roles in the emotional as well as cognitive functions

ANI
Published : Dec 30, 2019, 1:07 pm IST
Updated : Dec 30, 2019, 1:07 pm IST

Study reveals that evolutionary changes in human brain, potential reason of anxiety.

VMAT 1 contains two mutations or the genome changes which are human-specific. (Photo: ANI)
 VMAT 1 contains two mutations or the genome changes which are human-specific. (Photo: ANI)

Washington: New research found that evolutionary changes in the human brain could be a potential cause of the development of anxiety. Neurochemicals like dopamine and serotonin play significant roles in the emotional as well as cognitive functions of the human brain. Vesicular monoamine transporter 1 (VMAT1) is one of the many genes that are majorly responsible for regulating neuronal signalling and for transporting neurotransmitters.

The research team of the Tohoku University reconstructed ancestral VMAt1 proteins for their study which further revealed the functional changes that have taken place in the neurotransmitter uptake of VMAT1 during the course of human evolution. The team of researchers including Professor Masakado Kawata and PhD candidate Daiki Sato of the Graduate School of Life Sciences at Tohoku University previously found out that VMAT1 is one of the genes that had evolved through the human lineage.

VMAT 1 contains two mutations or the genome changes which are human-specific. In the study, the researchers revealed the evolutionary changes present in the uptake of neurotransmitters through the reconstruction of ancestral VMAT1 proteins. The researchers began by applying a fluorescent substrate for visualising and quantifying the neurotransmitter uptake of every genotype.

The researchers found out that the ancestral VMAT1 protein exhibited an increased uptake of neurotransmitters as compared to the derived genotype which is shown to be associated with depression and/or anxiety in contemporary human populations.

"This result of our study reveals that our ancestors may have been able to withstand higher levels of anxiety or depression," said the authors of the study. The researchers would next try to get a better understanding of how the variants contributed to our brain evolution. "This would be the striking evidence that links the evolution of our genome and brain," said the authors of the study.

Tags: anxiety, depression, neuro health
ADVERTISEMENT
ADVERTISEMENT