Washington: While most of us prefer keeping our distance from oil, researchers say that consuming oil in a well-balanced ketogenic diet is actually beneficial for your skin. "This study leads to a broader understanding of possible effects of ketogenic diets with a very high-fat content on skin inflammation and underlines the importance of the composition of fatty acids in the diet," said co-lead investigator, Barbara Kofler, PhD, Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria.
"We found that a well-balanced ketogenic diet, limited primarily to long-chain triglycerides (LCTs) like olive oil, soybean oil, fish, nuts, avocado, and meats, does not exacerbate skin inflammation," explained Barbara Kofler.
"However, ketogenic diets containing high amounts of medium-chain triglycerides (MCTs) especially in combination with omega-3 fatty acids should be used with caution since they may aggravate pre-existing skin inflammatory conditions," added Barbara Kofler.
Ketogenic diets are increasingly popular because of their promise to treat a number of diseases and promote weight loss. They are currently being evaluated as a potential therapy in a variety of diseases and have been suggested to act as an anti-inflammatory in certain conditions, reported the study published in 'Journal of Investigative Dermatology'.
Dietary products containing coconut oil (high in MCTs) or fish oil (high in omega-3 fatty acids), consumed as part of a ketogenic diet, are marketed and used by the general population because of their reported health-promoting effects.
The investigators hypothesised that high-fat ketogenic diets would dampen psoriasiform-like skin inflammation progression and that partial supplementation of long-chain triglycerides (LCTs) with MCT and/or omega-3 fatty acids would further enhance these effects. Although the study did not confirm that hypothesis, it showed that an LCT-based ketogenic diet does not worsen skin inflammation.
Co-lead investigator Roland Lang, PhD, Department of Dermatology, Paracelsus Medical University, Salzburg, Austria, elaborated on the study's results, "Ketogenic diets supplemented with MCTs not only induce the expression of pro-inflammatory cytokines but also lead to an accumulation of neutrophils in the skin resulting in a worse clinical appearance of the skin of the mice.
"Neutrophils are of particular interest since they are known to express a receptor for MCTs and therefore a ketogenic diet containing MCTs may have an impact on other neutrophil-mediated diseases not limited to the skin," added Roland Lang.
